Publikationen 2021

ORIGINALARBEITEN 2021

1. Chitinase 3 like 1 (CHI3L1) is a regulator of smooth muscle cell physiology and atherosclerotic lesion stability. Tsantilas P, Lao S, Wu Z, Eberhard A, Winski G, Vaerst M, Nanda V, Wang Y, Kojima Y, Ye J, Flores A, Jarr KU, Pelisek J, Eckstein HH, Matic L, Hedin U, Tsao PS, Paloschi , Maegdefessel L, Leeper NJ. Cardiovasc Res. 2021:20.
2. Acute aortic occlusion-a 16-year single-center experience. Sieber S, Stoklasa K, Reutersberg B, Stadlbauer T, Salvermoser M, Lang T, Busch A, Eckstein HH. J Vasc Surg. 2021: 25.
3. Absence of Consistent Sex Differences in Outcomes From Symptomatic Carotid Endarterectomy and Stenting Randomized Trials. Howard VJ, Algra A, Howard G, Bonati LH, de Borst GJ, Bulbulia R, Calvet D, Eckstein HH, Fraedrich G, Greving JP, Halliday A, Hendrikse J, Jansen O, Brown MM, Mas JL, Ringleb PA, Brott TG; Carotid Stenosis Trialists’ Collaboration. Stroke. 2021: 52(2):416-423.
4. Decreasing Spatial Variability of Individual Watershed Areas by Revascularization Therapy in Patients With High-Grade Carotid Artery Stenosis. Schmitzer L, Sollmann N, Kufer J, Kallmayer M, Eckstein HH, Zimmer C, Preibisch C, Kaczmarz S, Göttler J. J Magn Reson Imaging. 2021.
5. Relationship between regional settlement structure and hospital incidence, type of therapy and mortality of non-ruptured abdominal aortic aneurysms. Erk A, Trenner M, Salvermoser M, Reutersberg B, Schmid V, Eckstein HH, Kuehnl A. Z Evid Fortbild Qual Gesundhwes. 163:38-46.
6. Editor’s Choice – Risk of Stroke before Revascularisation in Patients with Symptomatic Carotid Stenosis: A Pooled Analysis of Randomised Controlled Trials. Fisch U, von Felten S, Wiencierz A, Jansen O, Howard G, Hendrikse J, Halliday A, Fraedrich G, Eckstein HH, Calvet D, Bulbulia R, Becquemin JP, Algra A, Rothwell P, Ringleb P, Mas JL, Brown MM, Brott TG, Bonati LH; Carotid Stenosis Trialists’ Collaboration. Eur J Vasc Endovasc Surg. 2021: 61(6):881-887.
7. Distribution of Care and Hospital Incidence of Carotid Endarterectomy and Carotid Artery Stenting: A Secondary Analysis of German Hospital Episode Data. Knappich C, Tsantilas P, Salvermoser M, Schmid S, Kallmayer M, Trenner M, Eckstein HH, Kuehnl A. Eur J Vasc Endovasc Surg. 2021.6.
8. Sex-Based Aortic Dissection Outcomes From the International Registry of Acute Aortic Dissection. Huckaby LV, Sultan I, Trimarchi S, Leshnower B, Chen EP, Brinster DR, Myrmel T, Estrera AL, Montgomery DG, Korach A, Eckstein HH, Coselli JS, Ota T, Kaiser CA, Eagle KA, Patel HJ, Gleason TG. Ann Thorac Surg. 2021.
9. Lenvatinib halts aortic aneurysm growth by restoring smooth muscle cell contractility. Busch A, Pauli J, Winski G, Bleichert S, Chernogubova E, Metschl S, Winter H, Trenner M, Wiegering A, Otto C, Fischer J, Reiser J, Werner J, Roy J, Brostjan C, Knappich C, Eckstein HH, Paloschi V, Maegdefessel L. JCI Insight. 2021:29.
10. Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms. Eilenberg W, Zagrapan B, Bleichert S, Ibrahim N, Knöbl V, Brandau A, Martelanz L, Grasl MT, Hayden H, Nawrozi P, Rajic R, Häusler C, Potolidis A, Schirwani N, Scheuba A, Klopf J, Teubenbacher P, Weigl MP, Kirchweger P, Beitzke D, Stiglbauer-Tscholakoff A, Panzenböck A, Lang I, Mauracher LM, Hell L, Pabinger I, Bailey MA, Scott DJA, Maegdefessel L, Busch A, Huk I, Neumayer C, Brostjan C. Transl Res. 2021: 233:32-46.
11. Novel Mutation in <i>LOX</i> Associates With a Complex Aneurysmal Vascular and Cardiac Phenotype. Cirnu A, Kolokotronis K, Walz K, Kilinç A, Janz A, Williams T, Busch A, Rost S, Gerull B. Circ Genom Precis Med. 2021: 14(1):e003217.
12. Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge-Mediated Monocyte Adhesion. Schumski A, Ortega-Gómez A, Wichapong K, Winter C, Lemnitzer P, Viola JR, Pinilla-Vera M, Folco E, Solis-Mezarino V, Völker-Albert M, Maas SL, Pan C, Perez Olivares L, Winter J, Hackeng T, Karlsson MCI, Zeller T, Imhof A, Baron RM, Nicolaes GAF, Libby P, Maegdefessel L, Kamp F, Benoit M, Döring Y, Soehnlein O. Circulation. 2021: 143(3):254-266.
13. Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases. Paloschi V, Sabater-Lleal M, Middelkamp H, Vivas A, Johansson S, van der Meer A, Tenje M, Maegdefessel L. Cardiovasc Res. 2021.
14. MicroRNA miR-29b regulates diabetic aortic remodeling and stiffening. Schellinger IN, Wagenhäuser M, Chodisetti G, Mattern K, Dannert A, Petzold A, Jakubizka-Smorag J, Emrich F, Haunschild J, Schuster A, Schwob E, Schulz K, Maegdefessel L, Spin JM, Stumvoll M, Hasenfuß G, Tsao PS, Raaz U. Mol Ther Nucleic Acids. 2021: 24(24):188-99.
15. Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification. Seime T, Akbulut AC, Liljeqvist ML, Siika A, Jin H, Winski G, van Gorp RH, Karlöf E, Lengquist M, Buckler AJ, Kronqvist M, Waring OJ, Lindeman JHN, Biessen EAL, Maegdefessel L, Razuvaev A, Schurgers LJ, Hedin U, Matic L. Cells. 2021: 10(6):1276.
16. Multicompartmental non-invasive sensing of postprandial lipemia in humans with multispectral optoacoustic tomography. Fasoula NA, Karlas A, Kallmayer M, Milik AB, Pelisek J, Eckstein HH, Klingenspor M, Ntziachristos V. Molecular Metabolism. 2021: 47
17. MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm. Gao P, Gao P, Zhao J, Shan S, Luo W, Slivano OJ, Zhang W, Tabuchi A, LeMaire SA, Maegdefessel L, Shen YH, Miano JM, Singer HA, Long X. Redox Biol. 2021: 41: 101903.
18. Virtual Transcriptomics: Noninvasive Phenotyping of Atherosclerosis by Decoding Plaque Biology From Computed Tomography Angiography Imaging. Buckler AJ, Karlöf E, Lengquist M, Gasser TC, Maegdefessel L, Perisic Matic L, Hedin U. Arterioscler Thromb Vasc Biol. 2021: 41(5): 1738-1750.
19. Monocyte-Chemoattractant Protein-1 Levels in Human Atherosclerotic Lesions Associate With Plaque Vulnerability. Georgakis MK, van der Laan SW, Asare Y, Mekke JM, Haitjema S, Schoneveld AH, de Jager SCA, Nurmohamed NS, Kroon J, Stroes ESG, de Kleijn DPV, de Borst GJ, Maegdefessel L, Soehnlein O, Pasterkamp G, Dichgans M. Arterioscler Thromb Vasc Biol. 2021: 41(6): 2038-2048.
20. Multispectral optoacoustic tomography of peripheral arterial disease based on muscle hemoglobin gradients-a pilot clinical study. Karlas A,  Masthoff M, Kallmayer M, Helfen A, Bariotakis M, Fasoula NA, Schafers M, Seidensticker M, Eckstein HH, Ntziachristos V, Wildgruber M. ANNALS OF TRANSLATIONAL MEDICINE.2021:9(1).
21. Webinar on the S3-Guideline „Diagnostics, Therapy and Aftercare of Patients with extracranial Carotid Stenosis“. Eckstein HH, Kuhnl A, Berkefeld J, Lawall H, Storck M, Sander D. CHIRURG. 2021:92(4).
22. Diagnostic performance of quantitative and qualitative parameters for the diagnosis of aortic graft infection using [18F]-FDG PET/CT. Einspieler I, Mergen V, Wendorff H, Haller B, Eiber M, Schwaiger M, Nekolla SG, Mustafa M.
    J Nucl Cardiol 2021: 28(5): 2220 – 2228
23. Multispectral optoacoustic tomography of lipid and hemoglobin contrast in human carotid atherosclerosis. Karlas A, Kallmayer M, Bariotakis M, Fasoula NA, Liapis E, Hyafil F, Pelisek J, Wildgruber M, Eckstein HH, Ntziachristos V.
    Photoacoustics 2021: 23: 100283
24. Intraoperative completion studies in carotid endarterectomy: systematic review and meta-analysis of techniques and outcomes.
    Knappich C, Lang T, Tsantilas P, Schmid S, Kallmayer M, Haller B, Eckstein HH. Ann Transl Med 202; 9(14): 1201.
25. Deep Learning Predicts Heart Failure With Preserved, Mid-Range, and Reduced Left Ventricular Ejection Fraction From Patient Clinical Profiles. Alkhodari M, Jelinek HF, Karlas A, Soulaidopoulos S, Arsenos P, Doundoulakis I, Gatzoulis KA, Tsioufis K, Hadjileontiadis LJ, Khandoker AH. Front Cardiovasc Med: 2021; 8: 755968.
26. Multi-Aspect Optoacoustic Imaging of Breast Tumors under Chemotherapy with Exogenous and Endogenous Contrasts: Focus on Apoptosis and Hypoxia. Karlas A, Nunes A, Driessen W, Liapis E, Reber J. Biomedicines 2021, 9(11), 1696
27. Carotid Plaque Phenotyping by Correlating Plaque Morphology from Computed Tomography Angiography with Transcriptional Profiling. Karlöf E, Buckler A, Liljeqvist ML, Lengquist M, Kronqvist M, Toonsi MA, Maegdefessel L, Matic LP, Hedin U . European Journal of Vascular and Endovascular Surgery 2021:62 (5) :716-726
28. Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization.Parallel Murine and Human Aortic Wall Genomics Reveals Metabolic Reprogramming as Key Driver of Abdominal Aortic Aneurysm Progression. Fasolo F, Jin H, Winski G, Chernogubova E, Pauli J, Winter H, Li DY, Glukha N, Bauer S, Metschl S, Wu Z, Koschinsky ML, Reilly M, Pelisek J, Kempf W, Eckstein HH, Soehnlein O, Matic L, Hedin U, Bäcklund A, Bergmark C, Paloschi V, Maegdefessel L.  Circulation 2021: 144 (19): 1567–1583
29. Parallel Murine and Human Aortic Wall Genomics Reveals Metabolic Reprogramming as Key Driver of Abdominal Aortic Aneurysm Progression. Gäbel G, Northoff BH, Balboa A, Becirovic-Agic M, Petri M, Busch A, Maegdefessel L, Mahlmann A, Ludwig S, Teupser D, de Waard V, Golledge J, Wanhainen A, Wågsäter D, Holdt LM, Lindeman JHN.
    Journal of the American Heart Association. 2021;10:e020231
30. Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis. Hinterdobler J, Schott S, Jin H, Meesmann A, Steinsiek AL, Zimmermann AS, Wobst J, Müller P, Mauersberger C, Vilne B, Baecklund A, Chen CS, Moggio A, Braster Q, Molitor M, Krane M, Kempf WE, Ladwig KH, Hristov M, Hulsmans M, Hilgendorf I, Weber C, Wenzel P, Scheiermann C, Maegdefessel L, Soehnlein O, Libby P, Nahrendorf M, Schunkert H, Kessler T, Sager HB.
    European Heart Journal 2021: 42 (39): 4077–4088
31. Contralateral Stenosis and Echolucent Plaque Morphology are Associated with Elevated Stroke Risk in Patients Treated with Asymptomatic Carotid Artery Stenosis within a Controlled Clinical Trial (SPACE-2). Reiff T, Eckstein HH, Mansmann U, Jansen O, Fraedrich G, Mudra H, Böckler D, Böhm M, Brückmann H, Debus ES, Fiehler J, Mathias K, Ringelstein EB, Schmidli J, Stingele R, Zahn R, Zeller T, Niesen WD, Barlinn K, Binder A, Glahn J, Ringleb PA, Collaborators.
    Journal of Stroke and Cerebrovascular Diseases 2021: 30 (9): 105940
32. Editor’s Choice – Risk of Stroke before Revascularisation in Patients with Symptomatic Carotid Stenosis: A Pooled Analysis of Randomised Controlled Trials. Fisch U, von Felten S, Wiencierz A, Jansen O, Howard G, Hendrikse J, Halliday A, Fraedrich G, Eckstein HH, Calvet D, Bulbulia R, Becquemin JP, Algra A, Rothwell P, Ringleb P, Mas JL, Brown MM, Brott TG, Bonati LH, Carotid Stenosis Trialists’ Collaboration. European Journal of Vascoular & Endovascular Surgery 2021: 61 (6): 881 – 887
33. European Stroke Organisation guideline on endarterectomy and stenting for carotid artery stenosis. Bonati LH, Kakkos S, Berkefeld J, de Borst GJ, Bulbulia R, Halliday A, van Herzeele I, Koncar I, McCabe DJ, Lal A, Ricco JB, Ringleb P, Taylor-Rowan M, Eckstein HH. European Stroke Journal 2021: 6 (2)
34. Management of Patients with Asymptomatic Carotid Stenosis May Need to Be Individualized: A Multidisciplinary Call for Action. Paraskevas KI, Mikhailidis DP, Baradaran H, Davies AH, Eckstein HH, Faggioli G, Fernandes JFE, Gupta A, Jezovnik MK, Kakkos SK, Katsiki N, Kooi ME, Lanza G, Liapis CD, Loftus IM, Millon A, Nicolaides AN, Poredos P, Pini R, Ricco JB, Rundek T, Saba L, Spinelli F, Stilo F, Sultan S, Zeebregts CJ, Chaturvedi S. Republication of J Stroke 2021; 23: 202-212
35. Vascular e-Learning During the COVID-19 Pandemic: The EL-COVID Survey. Patelis N, Bisdas T, Jing Z, Feng J, Trenner M, Tri Nugroho N, Ocke Reis PE, Elkouri S, Lecis A, Karam L, Roux DL, Ionac M, Berczeli M, Jongkind V, Yeung KK, Katsargyris A, Avgerinos E, Moris D, Choong A, Ng JJ, Cvjetko I, Antoniou GA, Ghibu P, Svetlikov A, Pedrajas FG, Ebben H, Stepak H, Chornuy A, Kostiv S, Ancetti S, Tadayon N, Mekkar A, Magnitskiy L, Fidalgo-Domingos L, Matheiken S, Sarutte Rosello ES, Isik A, Kirkilesis G, Kakavia K, Georgopoulos S. Annals of Vascular Surgery 2021: 77: 63-70
36. Translating mouse models of abdominal aortic aneurysm to the translational needs of vascular surgery. Busch A, Bleichert S, Ibrahim N, Wortmann M, Eckstein HH, Brostjan C, Wagenhäuser MU, Goergen CJ, Maegdefessel L.. JVS-Vascular Science 2021: 2: 219-234
37. Computational modeling of atherosclerotic plaque progression in carotid lesions with moderate degree of stenosis. Mantzaris MD, Siogkas PK, Tsakanikas VD, Potsika VT, Pleouras DS, Sakellarios AI, Karagiannis G, Galyfos G, Sigala F, Liasis N, Jovanovic M, Koncar IB, Kallmayer M, Fotiadis DI.  2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
38. Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy.  Halliday A, Bulbulia R, Bonati LH, Chester J, Cradduck-Bamford A, Peto R, Pan H, ACST-2 Collaborative Group. The Lancet 2021: 398 (10305): 1065-1073
39. SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study. COVIDSurg Collaborative, GlobalSurg Collaborative. Br. J Surg 2021: 1-8

REVIEWS 2021

1. Management of Patients with Asymptomatic Carotid Stenosis May Need to Be Individualized: A Multidisciplinary Call for Action. Paraskevas KI, Mikhailidis DP, Baradaran H, Davies AH, Eckstein HH, Faggioli G, Fernandes JFE, Gupta A, Jezovnik MK, Kakkos SK, Katsiki N, Kooi ME, Lanza G, Liapis CD, Loftus IM, Millon A, Nicolaides AN, Poredo P, Pini R, Ricco JB, Rundek T, Saba L, Spinelli F, Stilo F, Sultan S, Zeebregts CJ, Chaturvedi S. JOURNAL OF STROKE. 2021: 23(2):2287-6391.
2. Aortic Intimo-intimal Intussusception: A Pooled Analysis of Published Reports. Wu ZY, Miao YQ, Knappich C, Gao Q, Ma L, Chen ZG, Diao YP, Li YJ. Ann Vasc Surg. 2021.
3. Optoacoustic imaging in endocrinology and metabolism. Karlas A, Pleitez MA, Aguirre J, Ntziachristos V. Nature Reviews Endocrinology 2021: 17: 323–335
4. Author Correction: Optoacoustic imaging in endocrinology and metabolism. Karlas A, Pleitez MA, Aguirre J, Ntziachristos V. Nature Reviews Endocrinology 2021: 17: 511

COMMENTS/LETTERS 2021

1. In Reply. Eckstein HH. Dtsch Arztebl Int. 2021:118(6):290.

BÜCHER/BUCHBEITRÄGE 2021

1. Diener, Hans-Christoph (2021): Therapie-Handbuch Neurologie – Das Wichtigste für Klinik und Praxis, Hans-Christoph Diener (Hrsg.), 1.Auflage, München: Elsevier GmbH.