Lehre und Forschung
Publikationen 2018
ORIGINALARBEITEN 2018
- Increased variability of watershed areas in patients with high-grade carotid stenosis. Kaczmarz S, Griese V, Preibisch C, Kallmayer M, Helle M, Wustrow I, Petersen ET, Eckstein HH, Zimmer C, Sorg C, Göttler J. Neuroradiology. 2018 Mar;60(3):311-323. PMID: 29299616 Epub 2018 Jan 3.
- Expression and Cellular Localization of CXCR4 and CXCL12 in Human Carotid Atherosclerotic Plaques. Merckelbach S, van der Vorst EPC, Kallmayer M, Rischpler C, Burgkart R, Döring Y, de Borst GJ, Schwaiger M, Eckstein HH, Weber C, Pelisek J., Thromb Haemost. 2018 Jan;118(1):195-206. PMID: 29304539
- Extracellular Vesicles Secreted by Atherogenic Macrophages Transfer MicroRNA to Inhibit Cell Migration. Nguyen MA, Karunakaran D, Geoffrion M, Cheng HS, Tandoc K, Perisic Matic L, Hedin U, Maegdefessel L, Fish JE, Rayner KJ. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):49-63. PMID: 28882869
- Patient characteristics and in-hospital outcomes of emergency carotid endarterectomy and carotid stenting after stroke in evolution. Knappich C, Kuehnl A, Tsantilas P, Schmid S, Breitkreuz T, Kallmayer M, Zimmermann A, Eckstein HH. J Vasc Surg. 2018 Jan 27. pii: S0741-5214(17)32685-X. PMID: 29395420
- Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm. Di Gennaro A, Araújo AC, Busch A, Jin H, Wågsäter D, Vorkapic E, Caidahl K, Eriksson P, Samuelsson B, Maegdefessel L, Haeggström JZ. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1907-1912. PMID: 29432192
- Proefferocytic Therapy Promotes Transforming Growth Factor-β Signaling and Prevents Aneurysm Formation. Kojima Y, Werner N, Ye J, Nanda V, Tsao N, Wang Y, Flores AM, Miller CL, Weissman I, Deng H, Xu B, Dalman RL, Eken SM, Pelisek J, Li Y, Maegdefessel L, Leeper NJ. Circulation. 2018 Feb 13;137(7):750-753. PMID: 29440201
- Nationwide analysis of risk factors for in-hospital mortality in patients undergoing abdominal aortic aneurysm repair. Trenner M, Kuehnl A, Reutersberg B, Salvermoser M, Eckstein HH. Br J Surg. 2018 Mar;105(4):379-387. PMID: 29417985
- Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions. Jin H, Li DY, Chernogubova E, Sun C, Busch A, Eken SM, Saliba-Gustafsson P, Winter H, Winski G, Raaz U, Schellinger IN, Simon N, Hegenloh R, Matic LP, Jagodic M, Ehrenborg E, Pelisek J, Eckstein HH, Hedin U, Backlund A, Maegdefessel L. Mol Ther. 2018 Apr 4;26(4):1040-1055. PMID: 29503197
- Risk of Stroke or Death Is Associated With the Timing of Carotid Artery Stenting for Symptomatic Carotid Stenosis: A Secondary Data Analysis of the German Statutory Quality Assurance Database. Tsantilas P, Kuehnl A, Kallmayer M, Knappich C, Schmid S, Breitkreuz T, Zimmermann A, Eckstein HH. J Am Heart Assoc. 2018 Mar 27;7(7). pii: e007983. PMID: 29588311
- Operative treatment of diabetics with vascular complications : Secondary data analysis of diagnosis-related groups statistics from 2005 to 2014 in Germany. Olm M, Kühnl A, Knipfer E, Salvermoser M, Eckstein HH, Zimmermann A. Chirurg. 2018 Mar 27. PMID: 29589075
- The incidence of delayed complications in acute type B aortic dissections is underestimated. Reutersberg B, Trenner M, Haller B, Geisbüsch S, Reeps C, Eckstein HH. J Vasc Surg. 2018 Mar 31. pii: S0741-5214(18)30123-X. PMID: 29615351
- Cathepsin S is associated with degradation of collagen I in abdominal aortic aneurysm. Klaus V, Schmies F, Reeps C, Trenner M, Geisbüsch S, Lohoefer F, Eckstein HH, Pelisek J. Vasa. 2018 Apr 6:1-9 PMID: 29624112
- Systemic Upregulation of IL-10 (Interleukin-10) Using a Nonimmunogenic Vector Reduces Growth and Rate of Dissecting Abdominal Aortic Aneurysm. Adam M, Kooreman NG, Jagger A, Wagenhäuser MU, Mehrkens D, Wang Y, Kayama Y, Toyama K, Raaz U, Schellinger IN, Maegdefessel L, Spin JM, Hamming JF, Quax PHA, Baldus S, Wu JC, Tsao PS. Arterioscler Thromb Vasc Biol. 2018;38(8):1796-1805.
- Clinical implications of fracture-associated vascular damage in extremity and pelvic trauma. Gilbert F, Schneemann C, Scholz CJ, Kickuth R, Meffert RH, Wildenauer R, Lorenz U, Kellersmann R, Busch A. BMC Musculoskelet Disord. 2018;19(1):404.
- Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis. Cochain C, Vafadarnejad E, Arampatzi P, Pelisek J, Winkels H, Ley K, Wolf D, Saliba AE, Zernecke A. Circ Res. 2018;122(12):1661-1674.
- H19 Induces Abdominal Aortic Aneurysm Development and Progression. Li DY, Busch A, Jin H, Chernogubova E, Pelisek J, Karlsson J, Sennblad B, Liu S, Lao S, Hofmann P, Bäcklund A, Eken SM, Roy J, Eriksson P, Dacken B, Ramanujam D, Dueck A, Engelhardt S, Boon RA, Eckstein HH, Spin JM, Tsao PS, Maegdefessel L. Circulation. 2018;138(15):1551-1568.
- Noninvasive quantitative assessment of microcirculatory disorders of the upper extremities with 2D fluorescence optical imaging. Neumann J, Schmaderer C, Finsterer S, Zimmermann A, Steubl D, Helfen A, Berninger M, Lohöfer F, Rummeny EJ, Meier R, Wildgruber M. Clin Hemorheol Microcirc. 2018;70(1):69-81.
- How does descending aorta geometry change when it dissects? Rylski B, Muñoz C, Beyersdorf F, Siepe M, Reser D, Carrel T, Schoenhoff F, Schlensak C, Lescan M, Eckstein HH, Reutersberg B, Erbel R, Janosi RA, Czerny M. Eur J Cardiothorac Surg. 2018;53(4):815-821.
- Continuous Visceral and Distal Perfusion During „Off-pump“ Open Thoraco-abdominal Repair. Bíró G, Reutersberg B. Eur J Vasc Endovasc Surg. 2018; 56(6):901-901.
- Four Surgical Modifications to the Classic Elastase Perfusion Aneurysm Model Enable Haemodynamic Alterations and Extended Elastase Perfusion. Busch A, Chernogubova E, Jin H, Meurer F, Eckstein HH, Kim M, Maegdefessel L. Eur J Vasc Endovasc Surg. 2018;56(1):102-109.
- Spatial Analysis of Hospital Incidence and in Hospital Mortality of Abdominal Aortic Aneurysms in Germany: Secondary Data Analysis of Nationwide Hospital Episode (DRG) Data. Kuehnl A, Salvermoser M, Erk A, Trenner M, Schmid V, Eckstein HH. Eur J Vasc Endovasc Surg. 2018; 55(6):852-859.
- Regional frequency variation of revascularization procedures for carotid stenosis in Germany: Secondary data analysis of DRG data from 2012 to 2014. Kuehnl A, Salvermoser M, Knipfer E, Zimmermann A, Schmid V, Eckstein HH. GEFASSCHIRURGIE. 2018;23(Suppl 2):56-65.
- The vascular biobank-hands on. Reutersberg B, Peters A, Hakimi M, Pelisek J, Eckstein HH, Jahns R, Busch A. GEFASSCHIRURGIE. 2018;23(3):185-188.
- C-type natriuretic peptide slows down wound healing but promotes angiogenesis in SKH1-hr hairless mice (vol 10, pg 425, 2013). Kuehnl A, Pelisek J, Brzosko B, Ring A, Spindler N, Hatz R, Jauch KW, Eckstein HH, Langer S. Int Wound J. 2018;15(5):854-854.
- Impact of histological thrombus composition on preinterventional thrombus migration in patients with acute occlusions of the middle cerebral artery. Maegerlein C, Friedrich B, Berndt M, Lucia KE, Schirmer L, Poppert H, Zimmer C, Pelisek J, Boeckh-Behrens T, Kaesmacher J. Interv Neuroradiol. 2018;24(1):70-75.
- Directional Atherectomy With Antirestenotic Therapy vs Drug-Coated Balloon Angioplasty Alone for Common Femoral Artery Atherosclerotic Disease. Stavroulakis K, Schwindt A, Torsello G, Beropoulis E, Stachmann A, Hericks C, Bollenberg L, Bisdas T. J Endovasc Ther. 2018;25(1):92-99.
- Tapered Carotid Stents: An Essential Modification to Improve Carotid Artery Stenting Outcomes? Paraskevas KI, de Borst GJ, Eckstein HH. J Endovasc Ther. 2018;25(6): 771-772.
- Spectral Computed Tomography Angiography With a Gadolinium-based Contrast Agent: First Clinical Imaging Results in Cardiovascular Applications. Nadjiri J, Pfeiffer D, Straeter AS, Noël PB, Fingerle A, Eckstein HH, Laugwitz KL, Rummeny EJ, Braren R, Rasper M.
J Thorac Imaging. 2018;33(4):246-253. - Different perioperative antiplatelet therapies for patients treated with carotid endarterectomy in routine practice. Zimmermann A, Knappich C, Tsantilas P, Kallmayer M, Schmid S, Breitkreuz T, Storck M, Kuehnl A, Eckstein HH. J Vasc Surg. 2018;68(6):1753-1763.
- Outcomes of dialysis patients with critical limb ischemia after revascularization compared with patients with normal renal function. Meyer A, Fiessler C, Stavroulakis K, Torsello G, Bisdas T, Lang W, CRITISCH collaborators. J Vasc Surg. 2018;68(3):822-829e1.
- Clinical significance of perioperative changes in ankle-brachial index with regard to extremity-related outcome in non-diabetic patients with critical limb ischemia. Bischoff MS, Meisenbacher K, Peters AS, Weber D, Bisdas T, Torsello G, Böckler D, CRITISCH collaborators. Langenbecks Arch Surg. 2018; 403(6):741-748.
- Histological comparison of arterial thrombi in mice and men and the influence of Cl-amidine on thrombus formation. Novotny J, Chandraratne S, Weinberger T, Philippi V, Stark K, Ehrlich A, Pircher J, Konrad I, Oberdieck P, Titova A, Hoti Q, Schubert I, Legate KR, Urtz N, Lorenz M, Pelisek J, Massberg S, von Brühl ML, Schulz C. PLoS ONE. 2018; 13(1):e0190728.
- Immediate and Delayed Procedural Stroke or Death in Stenting Versus Endarterectomy for Symptomatic Carotid Stenosis. Müller MD, von Felten S, Algra A, Becquemin JP, Brown M, Bulbulia R, Calvet D, Eckstein HH, Fraedrich G, Halliday A, Hendrikse J, Gregson J, Howard G, Jansen O, Mas JL, Brott TG, Ringleb PA, Bonati LH, Carotid Stenosis Trialists’ Collaboration. Stroke. 2018;49(11):2715-2722.
- Prediction Models for Clinical Outcome After a Carotid Revascularization Procedure. Volkers EJ, Algra A, Kappelle LJ, Jansen O, Howard G, Hendrikse J, Halliday A, Gregson J, Fraedrich G, Eckstein HH, Calvet D, Bulbulia R, Brown MM, Becquemin JP, Ringleb PA, Mas JL, Bonati LH, Brott TG, Greving JP, Carotid Stenosis Trialists’ Collaboration.
Stroke. 2018;49(8):1880-1885. - Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects. Xu SW, Xu YN, Yin MM, Zhang SY, Liu P, Koroleva M, Si SY, Little PJ, Pelisek J, Jin ZG. Theranostics 2018; 8(11):3007-3021.
- Atherosclerosis Is an Epigenetic Disease. Xu SW, Pelisek J, Jin ZG. Trends Endocrinol Metab. 2018;29(11):739-742.
- Artificial Stroke Clots: How Wide is the Gap to the Real World? Berndt M, Prothmann S, Maegerlein C, Oberdieck P, Zimmer C, Hegge B, Pelisek J, Schirmer L, Poppert H, Boeckh-Behrens T. World Neurosurg. 2018;110():e90-e99
- Die Pathophysiologie des abdominalen Aortenaneurysmas. Busch A, Simon F, Schrimpf C, Menges AL, Zimmermann A, Eckstein HH, Maegdefessel L. Gefäßchirurgie (2018)
- Veränderung der Krankenhauskennzahlen von Diabetikern mit vaskulären Komplikationen in Deutschland: Sekundärdatenanalyse der DRG-Statistik von 2005 bis 2014. Olm M, Kuehnl A, Knipfer E, Salvermoser M, Eckstein HH, Zimmermann A. Gefasschirurgie. 2018:23(6):452-458.
- Regionale Häufigkeiten von revaskularisierenden Prozeduren bei Karotisstenose in Deutschland: Sekundärdatenanalyse der DRG-Statistik von 2012 bis 2014. Kuehnl A, Salvermoser M, Knipfer E, Zimmermann A, Schmid V, Eckstein HH. Gefasschirurgie. 2018:23(7):519-528.
- Resolution of Inflammation Through the Lipoxin and ALX/FPR2 Receptor Pathway Protects Against Abdominal Aortic Aneurysms. Petri MH, Thul S, Andonova T, Lindquist-Liljeqvist M, Jin H, Skenteris NT, Arnardottir H, Maegdefessel L, Caidahl K, Perretti M, Roy J, Bäck M. JACC: Basic to Translational Science. 2018:3(6):719-727.
- Altered DNA methylation indicates an oscillatory flow mediated epithelial-to-mesenchymal transition signature in ascending aorta of patients with bicuspid aortic valve. Björck HM, Du L, Pulignani S, Paloschi V, Lundströmer K, Kostina AS, Österholm C, Malashicheva A, Kostareva A, Evangelista A, Teixidó-Tura G, Maleki S, Franco-Cereceda A, Eriksson P, Dietz HC, Loeys B, Van Laer L, McCallion AS, Mertens L, Mital S, Mohamed SA, Andelfinger G. Scientific Reports. 2018:8(1).
- One-Year Results of First-Line Treatment Strategies in Patients With Critical Limb Ischemia (CRITISCH Registry). Stavroulakis K, Borowsk, M, Torsello G, Bisdas T, Adili F, Balzer K, Billing A, Böckler D, Brixner D, Debus ES, Eckstein HH, Florek HJ, Gkremoutis A, Grundmann R, Hupp T, Keck T, Gerß J, Wojciech K, Lang W, May B, Meyer A, Mühling B, Oberhuber A, Reinecke H, Reinhold C, Ritter RG, Schelzig H, Schlensack C, Schmitz-Rixen T, Schulte KL, Spohn M, Steinbauer M, Storck M, Trede M, Uhl C, Weis-Müller B, Wenk H, Zeller T, Zhorzel S, Zimmermann A. Journal of Endovascular Therapy. 2018:25(3):320-329.
- Does standoff material affect acoustic radiation force impulse elastography? A preclinical study of a modified elastography phantom. Hollerieth K, Gaßmann B, Wagenpfeil S, Kemmner S, Heemann U, Stock KF. Ultrasonography. 2018:37(2):140-148.
- Optoacoustic microscopy at multiple discrete frequencies. Kellnberger S, Soliman D, Tserevelakis GJ, Seeger M, Yang H, Karlas A, Prade L, Omar M, Ntziachristos V. Light Sci Appl. 2018:7:109.
- Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation. Li Y, Schnabl K, Gabler SM, Willershäuser M, Reber J, Karlas A, Laurila S, Lahesmaa M, U Din M, Bast-Habersbrunner A, Virtanen KA, Fromme T, Bolze F, O’Farrell LS, Alsina-Fernandez J, Coskun T, Ntziachristos V, Nuutila P, Klingenspor M. Cell. 2018:175(6):1561-1574.
- Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes. Clemmensen C, Jall S, Kleinert M, Quarta C, Gruber T, Reber J, Sachs S, Fischer K, Feuchtinger A, Karlas A, Simonds SE, Grandl G, Loher D, Sanchez-Quant E, Keipert S, Jastroch M, Hofmann SM, Nascimento EBM, Schrauwen P, Ntziachristos V, Cowley MA, Finan B, Müller TD, Tschöp MH. Nat Commun. 2018:9(1):4304.
- Use of Multispectral Optoacoustic Tomography to Diagnose Vascular Malformations. Masthoff M, Helfen A, Claussen J, Karlas A, Markwardt NA, Ntziachristos V, Eisenblätter M, Wildgruber M. JAMA Dermatol.
- Cardiovascular study group of the European Society of Molecular Imaging. Current and Emerging Preclinical Approaches for Imaging-Based Characterization of Atherosclerosis. Vigne J, Thackeray J, Essers J, Makowski M, Varasteh Z, Curaj A, Karlas A, Canet-Soulas E, Mulder W, Kiessling F, Schäfers M, Botnar R, Wildgruber M, Hyafil F. Mol Imaging Biol. 2018.
- Multispectral optoacoustic tomography of systemic sclerosis. Masthoff M, Helfen A, Claussen J, Roll W, Karlas A, Becker H, Gabriëls G, Riess J, Heindel W, Schäfers M, Ntziachristos V, Eisenblätter M, Gerth U, Wildgruber M. J Biophotonics. 2018.
- Multispectral Optoacoustic Tomography of Brown Adipose Tissue. Karlas A, Reber J, Liapis E, Paul-Yuan K, Ntziachristos V. Handb Exp Pharmacol.
- Non-invasive measurement of brown fat metabolism based on optoacoustic imaging of hemoglobin gradients. ReberJ, Willershäuser M, Karlas A, Paul-Yuan K, Diot G, Franz D, Fromme T, Ovsepian SV, Bézière N, Dubikovskaya E, Karampinos DC, Holzapfel C, Hauner H, Klingenspor M, Ntziachristos V. Cell Metab. 2018:27:689-701.
- Optoacoustic sensing of hematocrit to improve the accuracy of hybrid fluorescence-ultrasound intravascular imaging. Bozhko D, Karlas A, Gorpas D, Ntziachristos V. J Biophotonics. 2018.
REVIEWS 2018
- Non-coding RNAs: key regulators of smooth muscle cell fate in vascular disease. Leeper NJ, Maegdefessel L. Cardiovasc Res. 2018 Mar 15;114(4):611-621. PMID: 29300828
- Acute Limb Ischemia-Much More Than Just a Lack of Oxygen. Simon F, Oberhuber A, Floros N, Busch A, Wagenhäuser MU, Schelzig H, Duran M. Int J Mol Sci. 2018;19(2)
EDITORIALS/LETTERS 2018
- Editor’s Choice – High Annual Hospital Volume is Associated with Decreased in Hospital Mortality and Complication Rates Following Treatment of Abdominal Aortic Aneurysms: Secondary Data Analysis of the Nationwide German DRG Statistics from 2005 to 2013.
Trenner M, Kuehnl A, Salvermoser M, Reutersberg B, Geisbuesch S, Schmid V, Eckstein HH. Eur J Vasc Endovasc Surg. 2018;55(2):185-194. - European Society for Vascular Surgery Guidelines on the Management of Atherosclerotic Carotid and Vertebral Artery Disease. Eckstein HH. Eur J Vasc Endovasc Surg. 2018;55(1):1-2.
- H19 Induces AAA Development and Progression. Li DY, Jin H, Chernogubova E, Pelisek J, Karlsson J, Sennblad B, Liu S. J Vasc Surg 2018; 68(3):933-933.
- Invited commentary. Knappich C, Eckstein HH. J Vasc Surg. 2018; 68(5):1396-1397.
COMMENTS 2018
- TIMPing the Aorta: Smooth Muscle Cell-Specific Deletion of BMAL1 Limits Murine Abdominal Aortic Aneurysm Development. Winter C, Soehnlein O, Maegdefessel L. Arteriosclerosis, thrombosis, and vascular biology. 2018:38(5):982-983.
BÜCHER/BUCHBEITRÄGE 2018
ZITIERFÄHIGE ABSTRACTS 2018
- Hanging drops: a novel in vitro method to analyze human monocytes of relevance for atherosclerosis. Trattner M, Kehe K, Steinritz D, Pelisek J, Kuehnl A, Maegdefessel L.
Cardiovasc Res 2018;114:69-69. - Features of immunothrombosis in arterial thrombi of stroke and acute myocardial infarction patients. Novotny J, Boeckh-Behrens T, Poppert H, Oberdieck P, Chandraratne S, Hapfelmeier A, Titova A, Pelisek J, Massberg S, Schulz C. Eur Heart J. 2018;39:1330.
- Long non-coding RNA H19 induces abdominal aortic aneurysms. Li DY, Busch A, Jin HH, Hofmann P, Boon RA, Pelisek J, Paloschi V, Roy J, Eckstein HH, Spin JM, Tsao PS, Maegdefessel L. Eur Heart J. 2018;39:660.
- Atrophy of the Aneurysm Wall: Observations From Secondary Expansion After Endovascular Aneurysm Repair With Type II Endoleak. Busch A, Menges AL, Eckstein HH. J Vasc Surg. 2018;67(6):E103-E104.
- Inhibition of Abdominal Aortic Aneurysm Expansion in a Preclinical Atherosclerotic LDLR-/- Minipig Model by miR-29b-Coated Balloon Angioplasty. Busch A, Eckstein HH, Maegdefessel L. J Vasc Surg. 2018;67(6):236-236.
POSTER 2018